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Which of the following drugs must be kept in a safe or equivalent security container?

  1. Diphenhydramine

  2. Thiafentanil

  3. Ibuprofen

  4. Metformin

The correct answer is: Thiafentanil

Thiafentanil is classified as a Schedule II controlled substance due to its significant potential for abuse and dependence. The requirement for such drugs to be kept in a safe or equivalent security container is based on state and federal regulations aimed at preventing unauthorized access and misuse. Drugs in this category are subject to stricter storage requirements to ensure they are securely handled and to minimize the risks of diversion or accidental overdose. In contrast, diphenhydramine, ibuprofen, and metformin do not have the same level of abuse potential or regulatory restrictions as thiafentanil, and therefore, they are not mandated to be stored in a secure container. This distinction highlights the importance of proper drug storage practices regulated by law to ensure public health and safety regarding controlled substances.